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Alithea Biotechnology GmbH

AI-native life science solutions with transparent scientific execution and publication-linked evidence.

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Liebühl 2 A

79104 Freiburg, Germany

 

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Robert-Rössle-Straße 10, Gebäude 95

13125 Berlin, Germany

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Managing Director: Fanny Alicia Giannou

Commercial Register: Amtsgericht Freiburg

Registration Number: HRB 719811

VAT ID: DE325036990

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© 2026 Alithea Biotechnology GmbH. All rights reserved.

    HLA-Compass

    AI that understands immunopeptidomics.

    Ask a question. The copilot queries proprietary HLA data, picks the right MCP tool, and runs a governed analysis — so you can discover neoantigens in minutes, not months.

    Try nowSee the science
    0.00M+HLA peptides
    0Samples
    0+MCP tools
    0Healthy organs

    How it works

    From question to governed answer in three steps

    Step 1

    Ask in natural language

    Describe your research question — the copilot understands immunopeptidomics terminology, your data context, and available tools.

    Step 2

    AI selects and chains tools

    The copilot reads MCP descriptors from the tool marketplace, selects the right analytical module, configures inputs, and plans the execution.

    Step 3

    Governed execution with audit trail

    Every action is logged, budget-controlled, and traceable. You get results with full provenance — which data, which tool, which model.

    AI Copilot Playground

    Ask a question. Get a governed answer.

    Interact with our autonomous immunopeptidomics assistant. Select a prompt preset below, or type a custom question to see how the AI Copilot maps datasets and executes governed MCP tools in real-time.

    HLA-Compass AI Copilot
    PORT: 9002 · ACTIVE
    Which peptides from KRAS G12D are presented on HLA-A*02:01 in our lung tissue dataset?

    I will query the local ligandome database for KRAS G12D neoepitopes restricted to HLA-A*02:01, then filter against your active lung tissue cohorts.

    MCP Tool: ligandome-query
    source: lung_tissue_batch_04 · allele: A*02:01 · gene: KRAS · mutation: G12D
    3 peptides found · 2 above presentation threshold

    Found 3 peptides from KRAS G12D on HLA-A*02:01 in lung_tissue_batch_04. Two pass the presentation threshold with high confidence (q-value < 0.01).

    GovernedAudit: #LQ-28470.3 ACT
    Access Full Enterprise Suite

    Why this AI is different

    Most AI tools hallucinate on domain questions. HLA-Compass is grounded in proprietary data, governed by design, and built for pharma.

    AI-native architecture

    MCP-ready analytical tools the copilot discovers and chains autonomously. Agentic execution with full reasoning traces.

    Grounded in real data

    1.56 million HLA peptides across 4,425 samples from healthy organs, tumor tissues, and cell lines — evidence from real immunopeptidomics, not sequence prediction alone.

    Enterprise governance

    Immutable audit trail, row-level data isolation, credit-based billing, and supply chain attestation on every module.

    How HLA-Compass compares with alternatives

    Different approaches win for different jobs. Public atlases are better for open, citable reference checks, prediction tools are faster for sequence ranking, specialist services are stronger for bespoke wet-lab programs, and in-house stacks maximize control at the cost of time.

    Feature
    HLA-Compass
    Public atlases
    HLA Ligand Atlas / SysteMHC Atlas
    Prediction tools
    NetMHCpan / MHCflurry
    Specialist services
    Pure MHC / CRO workflows
    In-house stack
    Experimentally observed HLA peptidesIf instrumented
    Open/public reference access
    Private workspace for proprietary programsProject-based
    Healthy tissue context for off-target reviewPartialPartialPartial
    Self-serve interactive usagePartial
    Governed execution / audit layerPossible
    Custom workflow controlPartialPartial
    Time to first resultImmediateImmediateImmediateWeeksMonths

    Representative alternatives used here: HLA Ligand Atlas, SysteMHC Atlas, NetMHCpan/MHCflurry, and specialist discovery-service workflows such as Pure MHC.

    Latest Science

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